Article
Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled.
The British journal of surgery - 1 Feb 1997
Beck N E, Tomlinson I P, Homfray T, Hodgson S V, Harocopos C J, Bodmer W F
Abstract excerpt
BACKGROUND: Clinical screening is still the first-line approach to identification of families with hereditary non-polyposis colorectal cancer (HNPCC). The need for uniformity of diagnosis of the syndrome, particularly in multicentre studies, led to the establishment of a set of minimum diagnostic criteria, the 'Amsterdam criteria'. It is now known that HNPCC is caused by germline defects in the human mismatch...
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