Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High glucose induces a hypertrophic, senescent mesothelial cell phenotype after long in vivo exposure.

Nephron - 1 Jun 1999

Gotloib L, Shostak A, Wajsbrot V, Kushnier R

Abstract excerpt

Previous studies, done using our mouse model for population analysis of the mesothelium, showed evidence indicating that in vivo, long-term exposure (up to 30 days) of the peritoneum to high-glucose (4.25% D-glucose) concentration dialysis solutions resulted in a hypertrophic mesothelial phenotype characterized by increased cell surface area, multinucleation, low proliferative capabilities, reduced cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Culture Media
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Glucose

Share to Hydrogen-Ion Concentration

Share to Mitosis

Share to Peritoneum

Source

Identifiers

PMID: 10364709
DOI: 10.1159/000045393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High glucose induces a hypertrophic, senescent mesothelial cell phenotype after long in vivo exposure.PMID 10364709Read ↗

Changes in peritoneal mesothelial cells phenotype after chronic exposure to glucose or N-acetylglucosamine.Semantic proximity Read ↗

Accelerated senescence of human peritoneal mesothelial cells exposed to high glucose: the role of TGF-beta1.Semantic proximity Read ↗

Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose.Semantic proximity Read ↗

Human peritoneal mesothelial cells isolated from spent dialysate fluid maintain contaminating macrophages via production of macrophage colony stimulating factor.Semantic proximity Read ↗

Glucose-induced changes in the phenotype of human peritoneal mesothelial cells: effect of L-2-oxothiazolidine carboxylic acid.Semantic proximity Read ↗

Ongoing exposure to peritoneal dialysis fluid alters resident peritoneal macrophage phenotype and activation propensitySemantic proximity Read ↗

Ongoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity.Semantic proximity Read ↗

Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose-mediated peritoneal injury in mice.Semantic proximity Read ↗

Oxidative stress caused by a low concentration of hydrogen peroxide induces senescence-like changes in mouse gingival fibroblastsSemantic proximity Read ↗

Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains.Semantic proximity Read ↗

A free-radical hypothesis for the instability and evolution of genotype and phenotype in vitro.Semantic proximity Read ↗

High glucose level unmasks a genetic predisposition to enhanced extracellular matrix production in mesangial cells from the Milan normotensive strain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.