Genetic diversity of Helicobacter pylori type IV secretion system cagI and cagN genes and their association with clinical diseases.

doi:10.1038/s41598-023-37392-7

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Article

Genetic diversity of Helicobacter pylori type IV secretion system cagI and cagN genes and their association with clinical diseases.

Scientific reports - 24 Jun 2023

Azizimoghaddam Yasaman, Kermanpour Sadaf, Mirzaei Nasrin, Houri Hamidreza, Nabavi-Rad Ali, Asadzadeh Aghdaei Hamid, Yadegar Abbas, Zali Mohammad Reza

Abstract excerpt

A number of cagPAI genes in the Helicobacter pylori genome are considered the most evolved genes under a diversifying selection and evolutionary pressure. Among them, cagI and cagN are described as a part of the two different-operon of cagPAI that are involved in the T4SS machinery, but the defin...

Topics

Humans
Bacterial Proteins
Antigens, Bacterial
Helicobacter pylori
Type IV Secretion Systems
Iran
Virulence Factors
Genotype
Genetic Variation
Helicobacter Infections

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Identifiers

PMID: 37355714
DOI: 10.1038/s41598-023-37392-7
PMCID: PMC10290643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-37355714-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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