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Article

The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway.

Journal of cell science - 1 Aug 2006

Bashamboo Anu, Taylor A Helen, Samuel Kay, Panthier Jean-Jacque, Whetton Anthony D, Forrester Lesley M

Abstract excerpt

The stem cell factor (SCF)-KIT signal transduction pathway plays a role in the proliferation, differentiation and survival of a range of stem and progenitor cell types but little is known about its function in embryonic stem (ES) cells. We generated ES cells carrying a null allele of Kit as well as a knock-in allele that encodes an SCF-independent hybrid KIT receptor that can be activated by the FKBP binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16820414
DOI: 10.1242/jcs.03038

Genes

KIT
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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