Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequences of a hairpin structure in the 3'-untranslated region mediate regulation of human pulmonary surfactant protein B mRNA stability.

American journal of physiology. Lung cellular and molecular physiology - 15 May 2012

Huang Helen W, Payne David E, Bi Weizhen, Pan Su, Bruce Shirley R, Alcorn Joseph L

Abstract excerpt

The ability of pulmonary surfactant to reduce alveolar surface tension requires adequate expression of surfactant protein B (SP-B). Dexamethasone (DEX, 10(-7) M) increases human SP-B mRNA stability by a mechanism that requires a 126-nt-long segment (the 7.6S region) of the 3'-untranslated region (3'-UTR). The objective of this study was to identify sequences in the 7.6S region that mediate regulation of SP-B mRNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Dexamethasone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucocorticoids

Share to Inverted Repeat Sequences

Share to Plasmids

Share to Pulmonary Surfactant-Associated Protein B

Share to RNA Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 22367784
DOI: 10.1152/ajplung.00015.2012
PMCID: PMC3362263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequences of a hairpin structure in the 3'-untranslated region mediate regulation of human pulmonary surfactant protein B mRNA stability.PMID 22367784Read ↗

Human SP-A 3'-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone.Semantic proximity Read ↗

SP-A 3'-UTR is involved in the glucocorticoid inhibition of human SP-A gene expression.Semantic proximity Read ↗

Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution.Semantic proximity Read ↗

Differences in the translation efficiency and mRNA stability mediated by 5'-UTR splice variants of human SP-A1 and SP-A2 genes.Semantic proximity Read ↗

Single nucleotide polymorphism in 5'-flanking region reduces transcription of surfactant protein B gene in H441 cells.Semantic proximity Read ↗

Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants.Semantic proximity Read ↗

TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity.Semantic proximity Read ↗

Structural determinants of human ζ-globin mRNA stability.Semantic proximity Read ↗

Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene.Semantic proximity Read ↗

Identification of a novel DNA regulatory element in the rabbit surfactant protein B (SP-B) promoter that is a target for ATF/CREB and AP-1 transcription factors.Semantic proximity Read ↗

Analysis of genomic regions involved in regulation of the rabbit surfactant protein A gene in transgenic mice.Semantic proximity Read ↗

Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.