Article
Specific amino acid patterns define split specificities of HLA-B15 antigens enabling conversion from DNA-based typing to serological equivalents.
Immunogenetics - 1 Sept 2020
Duygu Burcu, Matern Benedict M, Wieten Lotte, Voorter Christina E M, Tilanus Marcel G J
Abstract excerpt
The HLA-B15 typing by serological approaches defined the serological subgroups (or splits) B62, B63, B75, B76, B77 and B70 (B71 and B72). The scarcity of sera with specific anti-HLA antibodies makes the serological typing method difficult to discriminate a high variety of HLA antigens, especially between the B15 antigen subgroups. Advancements in DNA-based technologies have led to a switch from serological typing...
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