Genic mutation rates in mammals: local similarity, chromosomal heterogeneity, and X-versus-autosome disparity.

Abstract excerpt

The reduction of mutation rates on the mammalian X chromosome relative to autosomes is most often explained in the literature as evidence of male-driven evolution. This hypothesis attributes lowered mutation rates on the X chromosome to the fact that this chromosome spends less time in the germline of males than in the germline of females. In contrast to this majority view, two articles argued that the patterns...

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