Article
Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.
The American journal of pathology - 1 Dec 1994
Dal Canto M C, Gurney M E
Abstract excerpt
Transgenic mice expressing mutant Cu,Zn superoxide dismutase (SOD), containing a substitution of glycine at position 93 by alanine, develop disease prevalently affecting motor neurons. Light microscopical and ultrastructural studies reveal that the earliest pathological features are microvesicula...
Topics
- Amyotrophic Lateral Sclerosis
- Animals
- Central Nervous System
- Disease Models, Animal
- Humans
- Inclusion Bodies
- Mice
- Mice, Transgenic
- Mutation
- Superoxide Dismutase
- Time Factors