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Article

Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.

The American journal of pathology - 1 Dec 1994

Dal Canto M C, Gurney M E

Abstract excerpt

Transgenic mice expressing mutant Cu,Zn superoxide dismutase (SOD), containing a substitution of glycine at position 93 by alanine, develop disease prevalently affecting motor neurons. Light microscopical and ultrastructural studies reveal that the earliest pathological features are microvesiculation of large neurons of the anterior horns of the spinal cord. These vacuoles originate from dilation of rough...

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Identifiers

PMID: 7992831
PMCID: PMC1887498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.PMID 7992831Read ↗

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