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The beta+-thalassemia mutation [IVS-II-5 (G-->C] creates an alternative splicing site in the second intervening sequence.

Hemoglobin - 1 May 1999

Jiang N H, Liang S

Abstract excerpt

We report a beta-thalassemia mutation [IVS-II-5 (G-->C)] in a Chinese family. Recently we cloned this beta-globin gene and studied its transient expression in murine erythroleukemia (MEL) cells. Both the thalassemic and normal beta-globin genes were isolated by polymerase chain reaction and TA-vector cloning. When the cloned beta-thalassemic globin gene was introduced into MEL cells, two kinds of spliced...

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PMID: 10335984
DOI: 10.3109/03630269908996161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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