[Repair of the splicing defect of thalassemic allele beta IVS-2-654 C-->T in cultured human erythroid cells by antisense RNA].

Article

[Repair of the splicing defect of thalassemic allele beta IVS-2-654 C-->T in cultured human erythroid cells by antisense RNA].

Zhonghua yi xue za zhi - 1 Nov 1997

Gu X, Gong L, Zhang W

Abstract excerpt

OBJECTIVE: To investigate the repair of the splicing defect of thalassemic allele beta IVS-2-654 C-->T (beta 654) in cultured human adult erythroid cells (hAE) by antisense RNA A2. METHODS: Vectors expressing antisense RNA fragments A2 which targeted against the aberrant splice sites of beta 654...

Topics

Adult
Alleles
Cells, Cultured
Child
DNA Repair
Erythroid Precursor Cells
Female
Genetic Therapy
Globins
Humans
Male
Point Mutation
RNA Splicing
RNA, Antisense
beta-Thalassemia

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