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Article

Reversal of aberrant splicing of beta-thalassemia allele by antisense RNA in vitro and in vivo.

Chinese medical journal - 1 Feb 1999

Zeng Y, Gu X, Chen Y, Gong L, Ren Z, Huang S

Abstract excerpt

OBJECTIVE: To investigate the reversal of aberrant splicing of beta-thalassemia allele (IVS-2-654 C-->T, beta 654) by antisense RNA in vitro and in vivo. METHODS: The vector expressing antisense RNA which targeted against the aberrant splice sites of beta 654 pre-mRNA was constructed in pcDNA3, and then used to repair the defective splicing of the mutant pre-mRNA in an in vitro transcription and splicing system,...

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PMID: 11593572

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Reversal of aberrant splicing of beta-thalassemia allele by antisense RNA in vitro and in vivo.PMID 11593572Read ↗

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Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides.Semantic proximity Read ↗

Correction of aberrant pre-mRNA splicing by antisense oligonucleotides in beta-thalassemia Egyptian patients with IVSI-110 mutation.Semantic proximity Read ↗

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