Article
Interleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy.
Clinical science (London, England : 1979) - 1 Jun 1999
Parry R G, Gillespie K M, Parnham A, Clark A G, Mathieson P W
Abstract excerpt
Minimal change nephropathy (MCN) is an important cause of nephrotic syndrome, especially in children, that is strongly associated with atopy and IgE production. The immunogenetics of MCN are poorly understood. Interleukin-4 (IL-4) is the critical cytokine involved in the development of atopy. Polymorphic regions in the genes encoding IL-4 itself and the IL-4 receptor have been demonstrated that may predispose to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.