Article
Polymorphisms in interleukin-4-related genes in patients with minimal change nephrotic syndrome.
Pediatric nephrology (Berlin, Germany) - 1 Mar 2009
Ikeuchi Yuka, Kobayashi Yasuko, Arakawa Hirokazu, Suzuki Michiko, Tamra Kazushi, Morikawa Akihiro
Abstract excerpt
Minimal change nephrotic syndrome (MCNS) in children is frequently associated with allergy and immunoglobulin E production. T helper subtype 2 cytokines, such as interleukin (IL)-4 and IL-13, may have an important role in the development of atopy. We investigated the association of genetic variations of IL-4 receptor alpha chain (IL-4Ralpha), IL-13 and signal transducer and activator of transcription 6 (STAT6)...
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