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Genetic Variants of Interleukin-4 in Romanian Patients with Idiopathic Nephrotic Syndrome.

Medicina (Kaunas, Lithuania) - 10 Feb 2022

Tieranu Ioana, Tieranu Cristian George, Dutescu Monica Irina, Berghea Camelia Elena, Balgradean Mihaela, Popa Olivia Mihaela

Abstract excerpt

Background and objectives: One of the most frequent glomerular diseases in the pediatric population is represented by the idiopathic nephrotic syndrome (INS). The exact mechanisms mediating the disease are still unknown, but several genetic factors have been studied for possible implications. Cytokines are considered to play a pivotal role in mediating INS disease progression, interleukin-4 (IL-4) exhibiting...

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PMID: 35208588
DOI: 10.3390/medicina58020265
PMCID: PMC8877980

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