Article
Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase.
Cancer research - 15 May 1999
Hu X, Herzog C, Zimniak P, Singh S V
Abstract excerpt
The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]]. The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Air Pollutants
- Alleles
- Amino Acid Substitution
- Carcinogens, Environmental
- Carcinoma, Squamous Cell
- DNA Adducts
- DNA Damage
- Genetic Predisposition to Disease
- Glutathione S-Transferase pi
- Glutathione Transferase
- Humans