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Article

Activity of allelic variants of Pi class human glutathione S-transferase toward chlorambucil.

Biochemical and biophysical research communications - 11 Nov 2000

Pandya U, Srivastava S K, Singhal S S, Pal A, Awasthi S, Zimniak P, Awasthi Y C, Singh S V

Abstract excerpt

Clinical efficacy of alkylating anticancer drugs, such as chlorambucil, is often limited by the emergence of drug resistant tumor cells. Increased glutathione (GSH) conjugation (inactivation) of alkylating anticancer drugs or their activated metabolites due to overexpression of the Pi class GSH S-transferase (hGSTP1-1) is believed to be an important mechanism in tumor cell resistance to alkylating agents....

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Identifiers

PMID: 11071881
DOI: 10.1006/bbrc.2000.3787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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