Article
Production of IL-4 and expression of CD40 ligand by human CD8 T cells.
The Journal of allergy and clinical immunology - 1 May 1999
Yanagihara Y, Kajiwara K, Koshio T, Basaki Y, Ikizawa K, Mori M, Akiyama K, Kawamura N, Sakiyama Y
Abstract excerpt
BACKGROUND: The role of CD8(+) T cells in IgE synthesis remains unclear. OBJECTIVE: The aim of this study was to investigate IL-4 production and CD40 ligand expression by human CD8(+) T cells. METHODS: We conducted functional and phenotypic analyses of human T cells in peritoneal washings from severe combined immunodeficiency mice reconstituted with PBMCs from normal and atopic human donors. We also examined the...
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