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Article

Bacteriophage T4 rnh (RNase H) null mutations: effects on spontaneous mutation and epistatic interaction with rII mutations.

Journal of bacteriology - 1 May 1999

Bebenek A, Smith L A, Drake J W

Abstract excerpt

The bacteriophage T4 rnh gene encodes T4 RNase H, a relative of a family of flap endonucleases. T4 rnh null mutations reduce burst sizes, increase sensitivity to DNA damage, and increase the frequency of acriflavin resistance (Acr) mutations. Because mutations in the related Saccharomyces cerevisiae RAD27 gene display a remarkable duplication mutator phenotype, we further explored the impact of rnh mutations upon...

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Identifiers

PMID: 10322013
DOI: 10.1128/JB.181.10.3123-3128.1999
PMCID: PMC93767

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Source receipt: pubmed, retrieved 7 Sept 2026.

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