Article
Role of yeast Rth1 nuclease and its homologs in mutation avoidance, DNA repair, and DNA replication.
Current genetics - 1 Jul 1998
Johnson R E, Kovvali G K, Prakash L, Prakash S
Abstract excerpt
The RTH1(RAD27) gene of Saccharomyces cerevisiae encodes a structure-specific endonuclease that cleaves 5'-ended single-stranded DNA at its junction with duplex DNA. Genetic and biochemical studies have indicated a role of Rth1 nuclease in the removal of RNA primers formed during DNA replication....
Topics
- Alkylation
- Amino Acid Sequence
- DNA Damage
- DNA Repair
- DNA Replication
- Enzyme Stability
- Exodeoxyribonuclease V
- Exodeoxyribonucleases
- Gene Deletion
- Molecular Sequence Data
- Mutation
- Repetitive Sequences, Nucleic Acid
- Saccharomyces cerevisiae
- Sequence Homology
- Structure-Activity Relationship