Article
Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels.
Nature neuroscience - 1 May 1999
Bourinet E, Soong T W, Sutton K, Slaymaker S, Mathews E, Monteil A, Zamponi G W, Nargeot J, Snutch T P
Abstract excerpt
P-type and Q-type calcium channels mediate neurotransmitter release at many synapses in the mammalian nervous system. The alpha 1A calcium channel has been implicated in the etiologies of conditions such as episodic ataxia, epilepsy and familial migraine, and shares several properties with native P- and Q-type channels. However, the exact relationship between alpha 1A and P- and Q-type channels is unknown. Here...
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