Article
A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.
The EMBO journal - 4 May 1999
Yagi R, Chen L F, Shigesada K, Murakami Y, Ito Y
Abstract excerpt
A protein module called the WW domain recognizes and binds to a short oligopeptide called the PY motif, PPxY, to mediate protein-protein interactions. The PY motif is present in the transcription activation domains of a wide range of transcription factors including c-Jun, AP-2, NF-E2, C/EBPalpha and PEBP2/CBF, suggesting that it plays an important role in transcriptional activation. We show here that mutation of...
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