Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2011

Lim Shen Kiat, Orhant-Prioux Magali, Toy Weiyi, Tan Kah Yap, Lim Yoon Pin

Abstract excerpt

WW-binding protein 2 (WBP2) has been demonstrated in different studies to be a tyrosine kinase substrate, to activate estrogen receptor α (ERα)/progesterone receptor (PR) transcription, and to play a role in breast cancer. However, the role of WBP2 tyrosine phosphorylation in regulating ERα function and breast cancer biology is unknown. Here, we established WBP2 as a tyrosine phosphorylation target of estrogen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen Receptor alpha
Share to Genes, src

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Animal

Share to Mice, Nude

Share to Neoplasms, Experimental

Share to Trans-Activators

Share to Tyrosine

Share to Wnt Proteins

Source

Identifiers

PMID: 21642474
DOI: 10.1096/fj.10-169136

Genes

WBP2
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway.PMID 21642474Read ↗

Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcriptionSemantic proximity Read ↗

WISP-2 as a Novel Estrogen-Responsive Gene in Human Breast Cancer CellsSemantic proximity Read ↗

Wwox inactivation enhances mammary tumorigenesis.Semantic proximity Read ↗

WBP2 Negatively Regulates Hippo Pathway By Competitively Binding To WWC3 With LATS1 To Promote The Malignant Phenotype Of Non-Small Cell Lung CancerSemantic proximity Read ↗

WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targetsSemantic proximity Read ↗

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axisSemantic proximity Read ↗

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.Semantic proximity Read ↗

WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in miceSemantic proximity Read ↗

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOXSemantic proximity Read ↗

WIP is necessary for matrix invasion by breast cancer cellsSemantic proximity Read ↗

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

Tumour‐promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicatorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.