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Article

Genetic and physiologic characterization of ferric/cupric reductase constitutive mutants of Cryptococcus neoformans.

Infection and immunity - 1 May 1999

Nyhus K J, Jacobson E S

Abstract excerpt

Cryptococcus neoformans is a pathogenic yeast that causes meningitis in immunocompromised patients. Because iron acquisition is critical for growth of a pathogen in a host, we studied the regulation of the ferric reductase and ferrous uptake system of this organism. We isolated 18 mutants, representing four independent loci, with dysregulated ferric reductase. The mutant strains had >10-fold higher than wild-type...

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Identifiers

PMID: 10225895
DOI: 10.1128/IAI.67.5.2357-2365.1999
PMCID: PMC115978

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