Novel protein-DNA interactions associated with increased immunoglobulin transcription in response to antigen plus interleukin-5.

doi:10.1128/mcb.11.10.5197-5205.1991

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Article

Novel protein-DNA interactions associated with increased immunoglobulin transcription in response to antigen plus interleukin-5.

Molecular and cellular biology - 1 Oct 1991

Webb C F, Das C, Eaton S, Calame K, Tucker P W

Abstract excerpt

Although much has been learned about basal levels of immunoglobulin (Ig) transcription, the regulatory effects of cytokines and antigen (Ag) upon Ig expression in lymphocytes have not been fully characterized. We previously reported that Ag plus interleukin-5 (IL-5) caused increased steady-state Ig mRNA levels in Ag-specific cell lines. In this study, we have identified a region between -250 and -125 bp 5' of the...

Topics

Animals
Antigens
Base Sequence
DNA-Binding Proteins
Gene Expression Regulation
Genes, Immunoglobulin
HeLa Cells
Hemocyanins
Humans
Immunoglobulin Variable Region
Immunoglobulin mu-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-5

L Cells

Lipopolysaccharides

Mice

Molecular Sequence Data

Mutation

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1922039
DOI: 10.1128/mcb.11.10.5197-5205.1991
PMCID: PMC361554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1922039-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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