Article
Novel protein-DNA interactions associated with increased immunoglobulin transcription in response to antigen plus interleukin-5.
Molecular and cellular biology - 1 Oct 1991
Webb C F, Das C, Eaton S, Calame K, Tucker P W
Abstract excerpt
Although much has been learned about basal levels of immunoglobulin (Ig) transcription, the regulatory effects of cytokines and antigen (Ag) upon Ig expression in lymphocytes have not been fully characterized. We previously reported that Ag plus interleukin-5 (IL-5) caused increased steady-state Ig mRNA levels in Ag-specific cell lines. In this study, we have identified a region between -250 and -125 bp 5' of the...
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