Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ethanol Inhibits L1-mediated Neurite Outgrowth in Postnatal Rat Cerebellar Granule Cells

1 May 1999

Abstract excerpt

The neuropathology of the effects of ethanol on the developing central nervous system are similar to those of patients with mutations in L1, a neural cell adhesion molecule. This observation suggests that inhibition of L1 plays a role in the pathogenesis of alcohol-related neurodevelopmental disorders. Here we examine the effects of ethanol on L1 homophilic binding and on L1-mediated neurite outgrowth. Ethanol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldose Reductase and Taurine
Share to Neurogenesis and neuroplasticity mechanisms
Share to Prenatal Substance Exposure Effects

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10224086
DOI: 10.1074/jbc.274.19.13264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ethanol Inhibits L1-mediated Neurite Outgrowth in Postnatal Rat Cerebellar Granule CellsPMID 10224086Read ↗

Missense mutations in the extracellular domain of the human neural cell adhesion molecule L1 reduce neurite outgrowth of murine cerebellar neurons.Semantic proximity Read ↗

Ethanol neuronotoxicity in the embryonic chick brain in ovo and in culture: interaction of the neural cell adhesion molecule (NCAM).Semantic proximity Read ↗

How does alcohol impair neuronal migration?Semantic proximity Read ↗

A new role for the cell adhesion molecule L1 in neural precursor cell proliferation, differentiation, and transmitter-specific subtype generation.Semantic proximity Read ↗

The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins.Semantic proximity Read ↗

Pathogenic human L1-CAM mutations reduce the adhesion-dependent activation of EGFR.Semantic proximity Read ↗

Clinical mutations in the L1 neural cell adhesion molecule affect cell-surface expression.Semantic proximity Read ↗

A Fragment of Adhesion Molecule L1 Binds to Nuclear Receptors to Regulate Synaptic Plasticity and Motor Coordination.Semantic proximity Read ↗

Ethanol increases cholinergic and decreases GABAergic neuronal expression in cultures derived from 8-day-old chick embryo cerebral hemispheres: interaction of ethanol and growth factors.Semantic proximity Read ↗

Mutational analysis of the L1 neuronal cell adhesion molecule identifies membrane-proximal amino acids of the cytoplasmic domain that are required for cytoskeletal anchorage.Semantic proximity Read ↗

Identification of the border between fibronectin type III homologous repeats 2 and 3 of the neural cell adhesion molecule L1 as a neurite outgrowth promoting and signal transducing domainSemantic proximity Read ↗

Early in ovo exposure of chick embryos to ethanol prevents the neuronotrophic effects of intracerebral NGF administration on cholinergic phenotypic expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.