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Article

Pathogenic human L1-CAM mutations reduce the adhesion-dependent activation of EGFR.

Human molecular genetics - 15 Oct 2009

Nagaraj Kakanahalli, Kristiansen Lars V, Skrzynski Adam, Castiella Carlos, Garcia-Alonso Luis, Hortsch Michael

Abstract excerpt

L1-cell adhesion molecule (L1-CAM) belongs to a functionally conserved group of neural cell adhesion molecules that are implicated in many aspects of nervous system development. In many neuronal cells the adhesive function of L1-type CAMs induces cellular signaling processes that involves the activation of neuronal tyrosine protein kinases and among other functions regulates axonal growth and guidance. Mutations...

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Source

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Identifiers

PMID: 19617634
DOI: 10.1093/hmg/ddp325
PMCID: PMC2748892

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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