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Article

Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic

1 Apr 1999

Abstract excerpt

The sperm chromatin structure assay (SCSA) was used to measure over 500 human semen samples from two independent studies: Study I, 402 samples from 165 presumably fertile couples wishing to achieve pregnancy over 12 menstrual cycles; Study II, samples from 115 patients seeking fertility counselling. The SCSA measures susceptibility to DNA denaturation in situ in spermatozoa exposed to acid for 30 s, followed by...

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PMID: 10221239
DOI: 10.1093/humrep/14.4.1039

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