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Intra-individual variation of the sperm chromatin structure assay DNA fragmentation index in men from infertile couples

6 Oct 2011

Abstract excerpt

BACKGROUND: The sperm chromatin structure assay (SCSA) is a valuable tool for prediction of fertility in vivo, with DNA fragmentation index (DFI) of 30% as a clinically useful cut-off level. Previous studies on fertile men have shown a high level of repeatability, with an intra-individual variability in DFI of ≈ 10%. However, conflicting data on how much the DFI fluctuates within individuals exist. The aim of the...

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PMID: 21984572
DOI: 10.1093/humrep/der328

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