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Article

Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.

The Journal of biological chemistry - 5 Aug 1990

Ashby M N, Edwards P A

Abstract excerpt

The assembly of a polyisoprenoid side chain and its transfer to para-hydroxybenzoate are the first two steps of coenzyme Q biosynthesis. In yeast these reactions are catalyzed by hexaprenyl pyrophosphate synthetase and PHB:polyprenyltransferase, respectively. We have screened nine complementation groups of yeast coenzyme Q mutants for the activities of these two enzymes and found two strains deficient in either...

Topics

Alkyl and Aryl Transferases
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Dimethylallyltranstransferase
Gene Library
Genes, Fungal
Genetic Complementation Test
Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Plasmids

Prohibitins

Protein Conformation

Rats

Restriction Mapping

Saccharomyces cerevisiae

Source

Identifiers

PMID: 2198286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2198286-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.PMID 2198286Read ↗

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