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Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells.

Glycobiology - 1 Dec 2010

Rush Jeffrey S, Matveev Sergey, Guan Ziqiang, Raetz Christian R H, Waechter C J

Abstract excerpt

During evolution the average chain length of polyisoprenoid glycosyl carrier lipids increased from C55 (prokaryotes) to C75 (yeast) to C95 (mammalian cells). In this study, the ability of the E. coli enzyme, undecaprenyl pyrophosphate synthase (UPPS), to complement the loss of the yeast cis-isoprenyltransferase in the rer2Δ mutant was tested to determine if (55)dolichyl phosphate (Dol-P) could functionally...

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PMID: 20685834
DOI: 10.1093/glycob/cwq107
PMCID: PMC3003547

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