Article
Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae.
Biochemical Society transactions - 1 Dec 2005
Vavassori S, Wang K, Schweizer L M, Schweizer M
Abstract excerpt
The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho-D-ribosyl-1(alpha)-pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result of this central position, perturbations in its synthesis can give rise to many unexpected cellular events, such as impaired cell integrity. We have taken advantage of S....
Topics
- Molecular Structure
- Peptides
- Phenotype
- Phosphoribosyl Pyrophosphate
- Phylogeny
- Ribose-Phosphate Pyrophosphokinase
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins