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Article

Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae.

Biochemical Society transactions - 1 Dec 2005

Vavassori S, Wang K, Schweizer L M, Schweizer M

Abstract excerpt

The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho-D-ribosyl-1(alpha)-pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result of this central position, perturbations in its synthesis can give rise to many unexpected cellular events, such as impaired cell integrity. We have taken advantage of S....

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PMID: 16246134
DOI: 10.1042/BST0331418

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