Article
Possible genetic association between interleukin-1alpha gene polymorphism and the severity of chronic polyarthritis.
European cytokine network - 1 Mar 1999
Jouvenne P, Chaudhary A, Buchs N, Giovine F S, Duff G W, Miossec P
Abstract excerpt
Interleukin-1 (IL-1) has been implicated in the pathogenesis of rheumatoid arthritis (RA). IL-1alpha gene polymorphism was analysed for the exon V and promoter region in 51 patients with destructive and 47 with non-destructive RA, as well as in 94 controls. The two biallelic polymorphisms in the promoter region and the exon V were 100% linked. The rare IL-1A2 allele carriage rate was 45% in the control...
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