Article
The tau gene A0 polymorphism in progressive supranuclear palsy and related neurodegenerative diseases.
Journal of neurology, neurosurgery, and psychiatry - 1 May 1999
Morris H R, Janssen J C, Bandmann O, Daniel S E, Rossor M N, Lees A J, Wood N W
Abstract excerpt
Progressive supranuclear palsy is characterised pathologically by the deposition of neurofibrillary tangles consisting of tau protein. Patients with the disease have been reported to have a more frequent occurrence of one allele of an intronic polymorphism of the tau gene. Other diseases which may involve tau deposition include frontotemporal dementia and corticobasal degeneration. This polymorphism has been...
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