Significant changes in the tau A0 and A3 alleles in progressive supranuclear palsy and improved genotyping by silver detection.

doi:10.1001/archneur.55.8.1122

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Article

Significant changes in the tau A0 and A3 alleles in progressive supranuclear palsy and improved genotyping by silver detection.

Archives of neurology - 1 Aug 1998

Oliva R, Tolosa E, Ezquerra M, Molinuevo J L, Valldeoriola F, Burguera J, Calopa M, Villa M, Ballesta F

Abstract excerpt

BACKGROUND: Progressive supranuclear palsy (PSP) is characterized by intraneuronal inclusions of neurofibrillary tangles formed by aggregated tau protein. A significant association between the tau gene A0/A0 genotype and PSP recently has been reported. OBJECTIVES: To determine if a significant as...

Topics

Aged
Alleles
Case-Control Studies
DNA Primers
Female
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Supranuclear Palsy, Progressive
tau Proteins

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