Article
Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection.
Journal of virology - 1 Dec 1998
Monaco M C, Jensen P N, Hou J, Durham L C, Major E O
Abstract excerpt
Progressive multifocal leukoencephalopathy is a demyelinating disease of the human central nervous system that results from lytic infection of oligodendrocytes by the polyomavirus JC (JCV). Originally, JCV was thought to replicate exclusively in human glial cells, specifically oligodendrocytes. H...
Topics
- Adolescent
- Adult
- Base Sequence
- Child
- Child, Preschool
- Cloning, Molecular
- DNA Primers
- DNA, Viral
- Genetic Variation
- Genome, Viral
- Humans
- JC Virus
- Lymphocytes
- Middle Aged
- Molecular Sequence Data
- Palatine Tonsil
- Polymerase Chain Reaction
- Polyomavirus Infections