Article
The role of 2'-5' oligoadenylate-activated ribonuclease L in apoptosis.
Cell death and differentiation - 1 Apr 1998
Castelli J C, Hassel B A, Maran A, Paranjape J, Hewitt J A, Li X L, Hsu Y T, Silverman R H, Youle R J
Abstract excerpt
Apoptosis of viral infected cells appears to be one defense strategy to limit viral infection. Interferon can also confer viral resistance by the induction of the 2-5A system comprised of 2'-5' oligoadenylate synthetase (OAS), and RNase L. Since rRNA is degraded upon activation of RNase L and during apoptosis and since both of these processes serve antiviral functions, we examined the role RNase L may play in...
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