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Article

RNase L Plays a Role in the Antiviral Response to West Nile Virus

24 Feb 2006

Abstract excerpt

Alleles at the Flv locus determine disease outcome after a flavivirus infection in mice. Although comparable numbers of congenic resistant and susceptible mouse embryo fibroblasts (MEFs) are infected by the flavivirus West Nile virus (WNV), resistant MEFs produce approximately 100- to 150-fold lower titers than susceptible ones and flavivirus titers in the brains of resistant and susceptible animals can differ by...

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PMID: 16501108
DOI: 10.1128/jvi.80.6.2987-2999.2006

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