Article
Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.
Genomics - 1 Oct 2001
Kratz C P, Emerling B M, Donovan S, Laig-Webster M, Taylor B R, Thompson P, Jensen S, Banerjee A, Bonifas J, Makalowski W, Green E D, Le Beau M M, Shannon K M
Abstract excerpt
Monosomy 7 and deletion of 7q are recurring abnormalities in malignant myeloid diseases. Here we extensively characterize an approximately 2-Mb commonly deleted segment (CDS) of 7q22 bounded by D7S1503 and D7S1841. Approximately 1.8 Mb of sequence have been generated from this interval, facilitating the construction of a transcript map that includes large numbers of genes and ESTs. The intron/exon organization of...
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