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Article

9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques.

Antimicrobial agents and chemotherapy - 1 Nov 1996

Van Rompay K K, Cherrington J M, Marthas M L, Berardi C J, Mulato A S, Spinner A, Tarara R P, Canfield D R, Telm S, Bischofberger N, Pedersen N C

Abstract excerpt

The long-term therapeutic and toxic effects of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated in simian immunodeficiency virus (SIV)-infected newborn rhesus macaques. Four untreated SIV-infected newborn macaques developed persistently high levels of viremia, and three of the four animals had rapidly fatal disease within 3 months. In contrast, long-term PMPA treatment of four newborn macaques starting...

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Identifiers

PMID: 8913470
DOI: 10.1128/AAC.40.11.2586
PMCID: PMC163581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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