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Article

In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA.

Antiviral therapy - 1 Jan 1999

Wainberg M A, Miller M D, Quan Y, Salomon H, Mulato A S, Lamy P D, Margot N A, Anton K E, Cherrington J M

Abstract excerpt

9-(2-phosphonomethoxypropyl)adenine (PMPA) has demonstrated remarkable anti-simian immunodeficiency virus (SIV) activity in macaque models of SIV infection and transmission prevention. Recently, PMPA and its oral prodrug, bis-POC PMPA, have also shown potent anti-human immunodeficiency virus type 1 (HIV-1) activity in Phase I clinical studies. In vitro experiments were performed to address the resistance...

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Identifiers

PMID: 10682153
DOI: 10.1177/135965359900400205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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