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Article

Induction of apoptosis in cancer: new therapeutic opportunities

1 Jan 2002

Abstract excerpt

Autonomous cell proliferation is one of the hallmarks of cancer cells, driven by activated growth-promoting oncogenes. However, deregulated activation of these oncogenes also triggers apoptosis via multiple pathways. Among them, the ARF-p53 pathway appears to play a major role in mediating oncogene-induced apoptosis. Consequently, suppression of apoptosis by inactivation of p53 and other tumor suppressors is...

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PMID: 12523501
DOI: 10.1080/078538902321012405

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Source receipt: pubmed, retrieved 7 Sept 2026.

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