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Article

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.

Blood - 18 Dec 2014

Lu Elise Peterson, McLellan Michael, Ding Li, Fulton Robert, Mardis Elaine R, Wilson Richard K, Miller Christopher A, Westervelt Peter, DiPersio John F, Link Daniel C, Walter Matthew J, Ley Timothy J, Graubert Timothy A

Abstract excerpt

Apoptosis and the DNA damage responses have been implicated in hematopoietic development and differentiation, as well as in the pathogenesis of myelodysplastic syndromes (MDS) and leukemia. However, the importance of late-stage mediators of apoptosis in hematopoiesis and leukemogenesis has not been elucidated. Here, we examine the role of caspase-9 (Casp9), the initiator caspase of the intrinsic apoptotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25349173
DOI: 10.1182/blood-2014-06-582551
PMCID: PMC4271179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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