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Article

Mutations in the Hco-mptl-1 gene in a field-derived monepantel-resistant isolate of Haemonchus contortus.

International journal for parasitology. Drugs and drug resistance - 1 Aug 2017

Bagnall Neil H, Ruffell Angela, Raza Ali, Elliott Timothy P, Lamb Jane, Hunt Peter W, Kotze Andrew C

Abstract excerpt

Resistance to the anthelmintic drug monepantel (Zolvix®) has emerged in parasitic worms infecting sheep and goats. The mechanism of resistance in these cases is unknown. The drug targets nicotinic acetylcholine receptors belonging to the nematode-specific DEG-3 subfamily. We examined the receptor gene, Hco-mptl-1, in a highly Zolvix®-resistant and a -susceptible isolate of the parasitic nematode Haemonchus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28501715
DOI: 10.1016/j.ijpddr.2017.05.001
PMCID: PMC5430491

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