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Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span

1 Apr 1999

Abstract excerpt

Normal somatic cells undergo replicative senescence in vitro but the significance of this process in organismic aging remains controversial. We have shown previously that hemopoietic stem cells of common inbred strains of mice vary widely in cycling activity and that this parameter is inversely correlated with strain-dependent mean life span. To assess whether cell cycling and life span are causally related, we...

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PMID: 10094931
DOI: 10.1096/fasebj.13.6.707

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