Article
Alternative initiation of translation accounts for a 67/45 kDa dimorphism of the human estrogen receptor ERalpha.
Biochemical and biophysical research communications - 2 Apr 1999
Barraille P, Chinestra P, Bayard F, Faye J C
Abstract excerpt
The estrogen receptor protein, in the nuclear receptor superfamily, carries two transactivator domains designated AF1 and AF2. The activity of AF2, localized in the carboxy-terminal region, is ligand-dependent, whereas AF1 (amino-terminal) seems to be activated via the MAPKkinase pathway. Uterine and mammary cells exhibiting large amounts of ERalpha were the first estrogen target organs demonstrated. The response...
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