Article
The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha transcriptional activity depends upon the differentiation stage of the cell.
The Journal of biological chemistry - 18 Jun 2004
Mérot Yohann, Métivier Raphaël, Penot Graziella, Manu Dominique, Saligaut Christian, Gannon Frank, Pakdel Farzad, Kah Olivier, Flouriot Gilles
Abstract excerpt
The activity of the transactivation functions (activation function (AF)-1 and AF-2) of the estrogen receptor alpha (ERalpha) is cell-specific. This study aimed to decipher the yet unclear mechanisms involved in this differential cell sensitivity, with particular attention to the specific influence that cell differentiation may have on these processes. Hence, we comparatively evaluated the permissiveness of cells...
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