Article
Premature centromere division in patients with multiple endocrine neoplasia type 1.
Cancer genetics and cytogenetics - 1 Mar 1999
Sakurai A, Katai M, Itakura Y, Ikeo Y, Hashizume K
Abstract excerpt
Frequency of mitoses with premature centromere division (PCD) was examined in lymphocytes from subjects with multiple endocrine neoplasia type 1 (MEN 1). An increase in PCD after exposure to an alkylating agent was observed in subjects with MEN 1 who carry a heterozygous MEN1 gene mutation but not in normal controls or in affected subjects without the MEN1 gene mutation. These findings support the inclusion of...
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