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Article

Wild-type NM23-H1, but not its S120 mutants, suppresses desensitization of muscarinic potassium current.

Biochimica et biophysica acta - 8 Mar 1999

Otero A S, Doyle M B, Hartsough M T, Steeg P S

Abstract excerpt

NM23 (NDP kinase) modulates the gating of muscarinic K+ channels by agonists through a mechanism distinct from GTP regeneration. To better define the function of NM23 in this pathway and to identify sites in NM23 that are important for its role in muscarinic K+ channel function, we utilized MDA-MB-435 human breast carcinoma cells that express low levels of NM23-H1. M2 muscarinic receptors and GIRK1/GIRK4 channel...

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Share to Monomeric GTP-Binding Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10082974
DOI: 10.1016/s0167-4889(99)00009-9

Genes

NDP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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