[Genetic predisposition for the development of head and neck carcinomas].

doi:10.1055/s-2007-996823

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Article

[Genetic predisposition for the development of head and neck carcinomas].

Laryngo- rhino- otologie - 1 Jan 1999

Jahnke V, Matthias C, Bockmühl U, Strange R C

Abstract excerpt

BACKGROUND: While cigarette smoking and chronic alcohol consumption are the major risk factors for the development of head and neck cancer, it is assumed that genetic factors contribute to risk. Glutathione-S-transferase GSTM1 AB, GSTM3 BB and GSTP1 AA as well as TNF genotypes were determined from leucocyte DNA in 392 patients with head and neck carcinoma and 216 controls, with added immunohistochemical studies....

Topics

Alcohol Drinking
Carcinoma, Squamous Cell
Chromosome Aberrations
Genetic Predisposition to Disease
Genotype
Glutathione Transferase
Humans
Otorhinolaryngologic Neoplasms
Phenotype
Polymorphism, Genetic
Risk Factors
Smoking
Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 10080124
DOI: 10.1055/s-2007-996823

Genes

GSTM1
GSTM3
GSTP1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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