Article
[Cellular and neoplastic otorhinolaryngologic changes, molecular markers and therapeutic potential].
Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris - 1 Jun 2003
Blons H, Laccourreye O, Laurent-Puig P
Abstract excerpt
Head and neck cancer is believed to arise after accumulation of genetic alterations resulting at least partially from chronic exposure of the upper aerodigestive tract to tobacco carcinogens. Accumulation of somatic genetic events in genes implicated in cell growth and differentiation lead to cell transformation and to the acquisition of cancer phenotype. The most frequent alterations in head and neck cancer...
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